A variety of cardiovascular and metabolic disorders, as well as responses among the critically ill surgical patient to injury and repair are all modulated by local inflammatory responses. For example, the recruitment of neutrophils, monocytes, and platelets to the arterial wall is considered a critical step in the earliest stages of atherosclerosis, as well as restenosis following […]
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The development of bio-inspired materials will provide component building blocks for enabling advances in cell-based therapies, artificial organs, and engineered living tissues, all of which will define the evolving field of Reparative Medicine. Recombinant Engineered Protein Polymers as Elastin Analogues Synthetic Collagen Fiber Analogues Membrane-Mimetic systems
Recombinant protein engineering can significantly increase protein yield over that which can be achieved by extraction of a native protein from animal tissues and offers the ability to use human amino acid sequences, so as to avoid adverse immunological responses. However, the most important impact of this technology lies in the potential to introduce precise […]
Collagen comprises the major structural protein component of the extracellular matrix of higher organisms and collagen-based materials are prime candidates for tissue repair and replacement technologies. However, it remains a major challenge to emulate the unique structural and biological properties of native collagenous biomaterials in synthetic analogues. Collagens derived from animal sources are widely employed […]
Lipid-based membranes have attracted considerable attention due to their potential application as tools to probe cellular and molecular interactions and as bioactive coatings for biosensor or medical implant applications. In particular, phospholipids differing in chemical composition, degree of saturation and size have provided primary building blocks for membrane-based structures of varying geometry because of their […]
Although the repair of the abdominal wall is among the most common class of operations performed by general surgeons in the US, results remain far from ideal due to chronic inflammation, poor integration of implanted biomaterials, and infection. We have ongoing efforts to develop biomaterials that serve as artificial fascia for the repair of abdominal […]
Whole organ pancreatic allografts using current immunosuppresive protocols have an expected graft survival as high as 86% at one year and 74% at 5 years after transplantation. Despite these encouraging results, the risk of major perioperative morbidity, the associated complications of chronic immunosuppresion therapy, and the persistent shortage of donor organ tissue remain limitations of […]
The treatment of lower extremity vascular disease through the use of balloon or laser angioplasty, stenting, or atherectomy remains limited by a significant incidence of restenosis. Thus, new approaches that target thrombotic and inflammatory events, which contribute to restenosis and delayed vessel wall healing are required. We postulate that thrombin and purinergic dependant pathways can […]
The cause of an aortic aneurysm remains poorly understood and successful pharmacotherapy is lacking despite the role of aneurysms as a major source of morbidity and death. Unregulated inflammatory and tissue repair processes underlie the maladaptive response of the vascular wall that leads to aneurysm formation. Thus, there is great motivation for understanding […]